Het-PDB Navi2 (PDB: 2IDK)

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Ligands
Code	Name		Style	Show	Link
C2F	5-methyl-5,6,7,8-tetrahydrofolic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2IDK

Code :

2IDK PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal Structure of Rat Glycine N-Methyltransferase Complexed With Folate

Release Data :

2006-12-19

Compound :

mol_id	molecule	chains	synonym
1	Glycine N-methyltransferase	A,B,C,D	Folate-binding protein
	ec: 2.1.1.20

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli BL21(DE3) (taxid:469008)
	strain: Sprague-Dawley gene: GNMT expression_system_strain: BL21(DE3) expression_system_vector_type: pET17-b expression_system_plasmid: pR6

Authors :

Luka, Z., Pakhomova, S., Loukachevitch, L.V., Egli, M., Newcomer, M.E., Wagner, C.

Keywords :

Glycine N-Methyltransferase, rat, folate binding, transferase

Exp. method :

X-RAY DIFFRACTION ( 2.55 Å )

Citation :

5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.

Luka, Z.,Pakhomova, S.,Loukachevitch, L.V. et al.
(2007) J.Biol.Chem. 282 : 4069 - 4075

Chain :

A, B, C, D

UniProt :

P13255 (GNMT_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L- homocysteine + sarcosine	2.1.1.20	PubMed:12859184, PubMed:3838667
	left-to-right	PubMed:12859184

PDB ID: 2IDK