Brand  (β version)

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information
centroid:
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Ligands
Code Name Link
CP Phosphoric acid mono(formamide)ester
NVA Norvaline
SO4 Sulfate ion
Code : 2I6U
Header : TRANSFERASE
Title : Crystal Structure of Ornithine Carbamoyltransferase complexed with Carbamoyl Phosphate and L-Norvaline from Mycobacterium tuberculosis (Rv1656) at 2.2 A
Release Data : 2007-06-26
Compound :
mol_id molecule chains synonym
1 Ornithine carbamoyltransferase A,B,C OTCase
ec: 2.1.3.3
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: argF, Rv1656, MT1694, MTCY06H11.21
expression_system_strain: BL21(DE3)pLysS
expression_system_plasmid: PDEST17
Authors : Sankaranarayanan, R., Moradian, F., Cherney, L.T., Garen, C., Cherney, M.M., James, M.N.G., TB Structural Genomics Consortium (TBSGC)
Keywords : Mycobacterium tuberculosis, ornithine carbamyoltransferase, Carbamoyl phosphate, L-Norvaline, Structural Genomics, PSI, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism

Sankaranarayanan, R.,Cherney, M.M.,Cherney, L.T.  et al.
(2008)  J.Mol.Biol.  375 : 1052 - 1063

PubMed: 18062991
DOI: 10.1016/j.jmb.2007.11.025

Chain : A, B, C
UniProt : P0A5M8 (multiple entry names are found)
Reaction : -