Het-PDB Navi2 (PDB: 2HZI)

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Ligands
Code	Name		Style	Show	Link
JIN	6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-D]pyrimidin-7(8h)-one				PoSSuM

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Download interaction data: 2HZI

Code :

2HZI PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Abl kinase domain in complex with PD180970

Release Data :

2007-01-16

Compound :

mol_id	molecule	chains	synonym
1	Proto-oncogene tyrosine-protein kinase ABL1	A,B	p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1
	ec: 2.7.10.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: ABL1 expression_system_common: Fall armyworm

Authors :

Cowan-Jacob, S.W., Fendrich, G., Liebetanz, J., Fabbro, D., Manley, P.

Keywords :

tyrosine kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.70 Å )

Citation :

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.

Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A. et al.
(2007) ACTA CRYSTALLOGR.,SECT.D 63 : 80 - 93

Chain :

A, B

UniProt :

P00519 (ABL1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:20357770, PubMed:28428613
	-	PROSITE-ProRule:PRU10028, PubMed:20357770, PubMed:28428613

PDB ID: 2HZI