Brand  (β version)

PDB ID: 2HWH

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Ligands
Code Name Style Show Link
RNA 4-methyl-N-{(5e)-5-[(5-methyl-2-furyl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl}benzenesulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2HWH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HCV NS5B allosteric inhibitor complex
Release Data : 2006-11-07
Compound :
mol_id molecule chains
1 RNA-directed RNA polymerase (NS5B) (p68) A,B
ec: 2.7.7.48
fragment: HCV NS5B
Source :
mol_id organism_scientific expression_system
1 Hepatitis C virus  (taxid:11103) Escherichia coli  (taxid:562)
Authors : Yao, N.
Keywords : HCV, NS5B, Viral RNA-directed RNA Polymerase, RdRP, allosteric inhibitor, HCV inhibitor complex, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Yan, S.,Appleby, T.,Larson, G.  et al.
(2006)  Bioorg.Med.Chem.Lett.  16 : 5888 - 5891

PubMed: 16934455
DOI: 10.1016/j.bmcl.2006.08.056

Reaction

Chain : A, B
UniProt : P26663 (POLG_HCVBK)
Reaction: EC: Evidence:
Physiological Direction:
[Serine protease/helicase NS3]
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 		3.4.21.98 UniProtKB:P27958
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[Serine protease/helicase NS3]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 UniProtKB:P27958
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[Serine protease/helicase NS3]
ATP + H2O = ADP + H(+) + phosphate 		3.6.4.13 UniProtKB:P27958
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[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539, PubMed:20194503, PubMed:9343198
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