Brand  (β version)

PDB ID: 2HWF

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Ligands
Code Name Style Show Link
JEN 3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2HWF   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : A COMPARISON OF THE ANTI-RHINOVIRAL DRUG BINDING POCKET IN HRV14 AND HRV1A
Release Data : 1994-09-30
Compound :
mol_id molecule chains
1 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP1) 1
mol_id molecule chains
2 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP2) 2
mol_id molecule chains
3 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP3) 3
mol_id molecule chains
4 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP4) 4
Source :
mol_id organism_scientific expression_system
1 Human rhinovirus 1A  (taxid:12134) Homo sapiens  (taxid:9606)
expression_system_common: Human
expression_system_cell_line: HeLa cells
mol_id organism_scientific expression_system
2 Human rhinovirus 1A  (taxid:12134) Homo sapiens  (taxid:9606)
expression_system_common: Human
expression_system_cell_line: HeLa cells
mol_id organism_scientific expression_system
3 Human rhinovirus 1A  (taxid:12134) Homo sapiens  (taxid:9606)
expression_system_common: Human
expression_system_cell_line: HeLa cells
mol_id organism_scientific expression_system
4 Human rhinovirus 1A  (taxid:12134) Homo sapiens  (taxid:9606)
expression_system_common: Human
expression_system_cell_line: HeLa cells
Authors : Kim, K.H., Rossmann, M.G.
Keywords : RHINOVIRUS COAT PROTEIN, Icosahedral virus, Virus
Exp. method : X-RAY DIFFRACTION ( 3.8 Å )
Citation :

A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.

Kim, K.H.,Willingmann, P.,Gong, Z.X.  et al.
(1993)  J.Mol.Biol.  230 : 206 - 227

PubMed: 8383771
DOI: 10.1006/jmbi.1993.1137

Human Rhinovirus 14 Complexed with Antiviral Compound R 61837

Chapman, M.S.,Minor, I.,Rossmann, M.G.  et al.
(1991)  J.Mol.Biol.  217 : 455

Crystal Structure of Human Rhinovirus Serotype 1A (Hrv1A)

Kim, S.,Smith, T.J.,Chapman, M.S.  et al.
(1989)  J.Mol.Biol.  210 : 91

Structural Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14

Badger, J.,Minor, I.,Kremer, M.J.  et al.
(1988)  Biochemistry  85 : 3304

The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents that Inhibit Uncoating

Smith, T.J.,Kremer, M.J.,Luo, M.  et al.
(1986)  Science  233 : 1286

Structure of a Human Common Cold Virus and Functional Relationship to Other Picornaviruses

Rossmann, M.G.,Arnold, E.,Erickson, J.W.  et al.
(1985)  Nature  317 : 145

Reaction

Chain : 4
UniProt : P23008 (POLG_HRV1A)
Reaction: EC: Evidence:
Physiological Direction:
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 UniProtKB:P03300
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 UniProtKB:P03300
-
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222
-