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Ligands
Code Name Style Show Link
CEQ Ethyl-trimethyl-silane
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BGC Beta-D-glucopyranose
GAL Beta-D-galactopyranose
NGA 2-acetamido-2-deoxy-beta-D-galactopyranose
SIA N-acetyl-alpha-neuraminic acid
: Polysaccharide
Non-standard Residues
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Glycosylation
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Code : 2HRL   PDBj   RCSB PDB   PDBe
Header : CELL ADHESION
Title : Siglec-7 in complex with GT1b
Release Data : 2006-08-15
Compound :
mol_id molecule chains synonym
1 Sialic acid-binding Ig-like lectin 7 A Siglec-7, QA79 membrane protein, Adhesion inhibitory receptor molecule 1, AIRM-1, p75, D-siglec, CDw328 antigen
fragment: Ig-like V-type, N-terminal domain, residues 18-144
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
expression_system_common: Chinese hamster
expression_system_cell_line: CHO Lec1
expression_system_vector_type: plasmid
expression_system_plasmid: pDEF-Siglec-7
Authors : Attrill, H., Imamura, A., Sharma, R.S., Kiso, M., Crocker, P.R., van Aalten, D.M.F.
Keywords : Ig-like domain, Siglec, Ganglioside, Siglec-7, CELL ADHESION
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Siglec-7 Undergoes a Major Conformational Change When Complexed with the {alpha}(2,8)-Disialylganglioside GT1b

Attrill, H.,Imamura, A.,Sharma, R.S.  et al.
(2006)  J.Biol.Chem.  281 : 32774 - 32783

PubMed: 16895906
DOI: 10.1074/jbc.M601714200

Chain : A
UniProt : Q9Y286 (SIGL7_HUMAN)
Reaction : -