Brand  (β version)

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information
centroid:
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Ligands
Code Name Link
0G7 D-phenylalanyl-N-[(3s)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide
Code : 2HPP
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN LIGHT CHAIN L
ec: 3.4.21.5
fragment: UNP residues 328-363
mol_id molecule chains
2 ALPHA-THROMBIN HEAVY CHAIN H
ec: 3.4.21.5
fragment: UNP residues 364-622
mol_id molecule chains synonym
3 Prothrombin P Coagulation factor II
ec: 3.4.21.5
fragment: UNP residues 214-292
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Bos Taurus  (taxid:9913) Bovine
Authors : Tulinsky, A., Padmanabhan, K.
Keywords : HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SERINE PROTEINASE
Exp. method : X-RAY DIFFRACTION ( 3.3 Å )
Citation :

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.

Arni, R.K.,Padmanabhan, K.,Padmanabhan, K.P.  et al.
(1993)  Biochemistry  32 : 4727 - 4737

PubMed: 8387813
DOI: 10.1021/bi00069a006

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.E.,Ravichandran, K.G.  et al.
(1991)  J.Mol.Biol.  221 : 1379

The Refined Structure of the Epsilon-Aminocaproic Acid Complex of Human Plasminogen Kringle 4

Wu, T.-P.,Padmanabhan, K.,Tulinsky, A.  et al.
(1991)  Biochemistry  30 : 10589

Structure of Bovine Prothrombin Fragment 1 Refined at 2.25 Angstroms Resolution

Seshadri, T.P.,Tulinsky, A.,Skrzypczak-Jankun, E.  et al.
(1991)  J.Mol.Biol.  220 : 481

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Chain : P
UniProt : P00735 (THRB_BOVIN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.