Brand  (β version)

PDB ID: 2HHM

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Ligands
Code Name Style Show Link
GD Gadolinium atom PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2HHM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY
Release Data : 1993-10-31
Compound :
mol_id molecule chains
1 INOSITOL MONOPHOSPHATASE A,B
ec: 3.1.3.25
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: BRAIN
Authors : Bone, R.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Structure of inositol monophosphatase, the putative target of lithium therapy.

Bone, R.,Springer, J.P.,Atack, J.R.
(1992)  Proc.Natl.Acad.Sci.USA  89 : 10031 - 10035

PubMed: 1332026
DOI: 10.1073/pnas.89.21.10031

C/DNA Cloning of Human and Rat Brain Myo-Inositol Monophosphatase: Expression and Characterization of the Human Recombinant Enzyme

Mcallister, G.,Whiting, P.,Hammond, E.A.  et al.
(1992)  Biochem.J.  284 : 749

Reaction

Chain : A, B
UniProt : P29218 (IMPA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a myo-inositol phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:1377913, PubMed:17068342, PubMed:8068620, PubMed:8718889, PubMed:9462881
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1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:17068342, PubMed:8718889, PubMed:9462881
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1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:17068342
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1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:17068342, PubMed:9462881
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1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:17068342
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1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:17068342
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1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:17068342
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scyllo-inositol 1-phosphate + H2O = scyllo-inositol + phosphate - PubMed:17068342
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alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate 3.1.3.94 PubMed:9462881
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alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate - PubMed:17068342
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D-glucose 6-phosphate + H2O = D-glucose + phosphate - PubMed:17068342, PubMed:8718889
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beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate - PubMed:17068342
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glycerol 2-phosphate + H2O = glycerol + phosphate - PubMed:17068342
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adenosine 2'-phosphate + H2O = adenosine + phosphate - PubMed:17068342
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:17068342
ECO:0000269 | PubMed:8718889
ECO:0000269 | PubMed:9462881
ECO:0000303 | PubMed:23027737
ECO:0000303 | PubMed:8068621
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