Brand  (β version)

PDB ID: 2HA0

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Ligands
Code Name Style Show Link
CHH N,N,N-trimethyl-4-oxopentan-1-aminium PoSSuM
IOD Iodide ion PoSSuM
NWA 4,4-dihydroxy-N,N,N-trimethylpentan-1-aminium PoSSuM
P6G Hexaethylene glycol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 2HA0   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of mouse acetylcholinesterase complexed with 4-ketoamyltrimethylammonium
Release Data : 2006-07-18
Compound :
mol_id molecule chains synonym
1 Acetylcholinesterase A,B AChE
ec: 3.1.1.7
fragment: catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Homo sapiens  (taxid:9606)
expression_system_common: Human
expression_system_variant: LAMBDA ZAP
expression_system_cell_line: HEK 293
expression_system_cell: HUMAN EMBRYONIC KIDNEY CELLS (HEK)
Authors : Bourne, Y., Radic, Z., Sulzenbacher, G., Kim, E., Taylor, P., Marchot, P.
Keywords : HYDROLASE FOLD, SERINE ESTERASE, ACETYLCHOLINESTERASE, HOMODIMER, GLYCOSYLATED PROTEIN, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding

Bourne, Y.,Radic, Z.,Sulzenbacher, G.  et al.
(2006)  J.Biol.Chem.  281 : 29256 - 29267

PubMed: 16837465
DOI: 10.1074/jbc.M603018200

Reaction

Chain : A, B
UniProt : P21836 (ACES_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-