Brand  (β version)

PDB ID: 2H9E

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
NA Sodium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
Code Name Show
DTY D-tyrosine
LPD L-prolinamide
Glycosylation
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Structure summary

Code : 2H9E   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of FXa/selectide/NAPC2 ternary complex
Release Data : 2007-02-13
Compound :
mol_id molecule chains
1 Coagulation factor X heavy chain H
ec: 3.4.21.6
fragment: catalytic domain
mol_id molecule chains
2 Coagulation factor X light chain L
ec: 3.4.21.6
fragment: EGF-like 1 domain
mol_id molecule chains
3 Anti-coagulant protein C2 C
mol_id molecule chains
4 selectide inhibitor DTY-ILE-ARG-LEU-LPD peptide S
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common expression_system
3 Ancylostoma caninum  (taxid:29170) Dog hookworm Escherichia coli  (taxid:562)
mol_id organism_scientific
4
synthetic: yes
other_details: THE PEPTIDE WAS CHEMICALLY SYNTHESIZED.
Authors : Murakami, M.T., Geiger, G., Tulinsky, A., Arni, R.K.
Keywords : factor Xa, NAPc2, selectide, hydrolase-hydrolase inhibitor complex, blood clotting
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor Xa Complexed with the Anticoagulant Protein NAPc2 from the Hematophagous Nematode Ancylostoma caninum.

Murakami, M.T.,Rios-Steiner, J.,Weaver, S.E.  et al.
(2007)  J.Mol.Biol.  366 : 602 - 610

PubMed: 17173931
DOI: 10.1016/j.jmb.2006.11.040

Reaction

Chain : L
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
-
Chain : C
UniProt : Q16938 (Q16938_ANCCA)
Reaction : -