Het-PDB Navi2 (PDB: 2H48)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
CF0	Fluoromethane
PHQ	Benzyl chlorocarbonate

Download interaction data: 2H48

Code :

2H48 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of human caspase-1 (Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)

Release Data :

2006-06-06

Compound :

mol_id	molecule	chains
1	Caspase 1, isoform gamma	A
	ec: 3.4.22.36 fragment: large subunit, residues, 120-297

mol_id	molecule	chains
2	Caspase 1, isoform gamma	B
	ec: 3.4.22.36 fragment: small subunit, residues 317-404 mutation: C362A, C364A, C397A

mol_id	molecule	chains
3	N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide	C

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CASP1 expression_system_strain: BL21(DE3)Star expression_system_vector_type: Plasmid expression_system_plasmid: pGEX6P-1

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CASP1 expression_system_strain: BL21(DE3)Star expression_system_vector_type: Plasmid expression_system_plasmid: pGEX6P-1

mol_id	organism_scientific
3
	synthetic: yes

Authors :

Scheer, J.M., Wells, J.A., Romanowski, M.J.

Keywords :

allosteric side, z-VAD-FMK, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

A common allosteric site and mechanism in caspases

Scheer, J.M.,Romanowski, M.J.,Wells, J.A.
(2006) Proc.Natl.Acad.Sci.USA 103 : 7595 - 7600

PubMed: 16682620
DOI: 10.1073/pnas.0602571103

PDB ID: 2H48

Hetero Atom Contents

Structure summary

Reaction