Brand  (β version)

PDB ID: 2H31

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Ligands
Code Name Style Show Link
CO2 Carbon dioxide PoSSuM
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 2H31   PDBj   RCSB PDB   PDBe
Header : LIGASE, LYASE
Title : Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine biosynthesis
Release Data : 2007-01-30
Compound :
mol_id molecule chains synonym
1 Multifunctional protein ADE2 A Phosphoribosylaminoimidazole-succinocarboxamide synthase, Phosphoribosylaminoimidazole carboxylase
ec: 6.3.2.6, 4.1.1.21
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PAICS, ADE2, AIRC, PAIS
Authors : Li, S.-X., Tong, Y.-P., Xie, X.-C., Li, S.-G., Bi, R.-C.
Keywords : alpha-beta-alpha, LIGASE, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis.

Li, S.X.,Tong, Y.P.,Xie, X.C.  et al.
(2007)  J.Mol.Biol.  366 : 1603 - 1614

PubMed: 17224163
DOI: 10.1016/j.jmb.2006.12.027

Reaction

Chain : A
UniProt : P22234 (PUR6_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole- 4-carboxamido]succinate + ADP + 2 H(+) + phosphate 6.3.2.6 PubMed:17224163
left-to-right PubMed:31600779
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 4.1.1.21 PubMed:17224163, PubMed:31600779
right-to-left PubMed:31600779