Brand  (β version)

PDB ID: 2GZ8

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Ligands
Code Name Style Show Link
F3F S-[5-(trifluoromethyl)-4h-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate PoSSuM
Non-standard Residues
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Structure summary

Code : 2GZ8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease
Release Data : 2006-08-29
Compound :
mol_id molecule chains synonym
1 Replicase polyprotein 1ab A SARS-CoV main protease, pp1ab, ORF1AB
ec: 3.4.22.-
fragment: 3C-like proteinase
Source :
mol_id organism_scientific expression_system
1 SARS coronavirus  (taxid:227859) Escherichia coli BL21  (taxid:511693)
strain: sars
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pET32Xa/LIC
Authors : Lu, I.L., Wu, S.Y.
Keywords : SARS CoV main protease, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.97 Å )
Citation :

Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease

Lu, I.L.,Mahindroo, N.,Liang, P.H.  et al.
(2006)  J.Med.Chem.  49 : 5154 - 5161

PubMed: 16913704
DOI: 10.1021/jm060207o

Reaction

Chain : A
UniProt : P59641 (multiple entry names are found)
Reaction : -