Brand  (β version)

PDB ID: 2GEU

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Ligands
Code Name Style Show Link
COK [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3r)-3-hydroxy-4-{[3-({2-[(2-hydroxyethyl)dithio]ethyl}amino)-3-oxopropyl]amino}-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate PoSSuM
Non-standard Residues
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CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Structure summary

Code : 2GEU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A derivative, Form-II (RT)
Release Data : 2006-06-06
Compound :
mol_id molecule chains synonym
1 Pantothenate kinase A PANK, Pantothenic acid kinase
ec: 2.7.1.33
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
strain: H37Rv
gene: coaA(Rv1092c)
expression_system_strain: BL21 (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-28a(+) (NOVAGEN)
Authors : Das, S., Kumar, P., Bhor, V., Surolia, A., Vijayan, M.
Keywords : HOMODIMER, COA BIOSYNTHESIS, NUCLEOTIDE BINDING, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Invariance and variability in bacterial PanK: a study based on the crystal structure of Mycobacterium tuberculosis PanK.

Das, S.,Kumar, P.,Bhor, V.  et al.
(2006)  Acta Crystallogr.,Sect.D  62 : 628 - 638

PubMed: 16699190
DOI: 10.1107/S0907444906012728

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of pantothenate kinase from Mycobacterium tuberculosis

Das, S.,Kumar, P.,Bhor, V.  et al.
(2005)  ACTA CRYSTALLOGR.,SECT.F  61 : 65 - 67

PubMed: 16508093
DOI: 10.1107/S1744309104028040

Reaction

Chain : A
UniProt : P63810 (COAA_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) 2.7.1.33 -
-