Brand  (β version)

PDB ID: 2GCQ

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Ligands
Code Name Style Show Link
DOI 9-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-6-(phosphonooxy)-9h-purine PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
HDA Hadacidin PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2GCQ   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Fully ligated E.Coli Adenylosuccinate Synthetase with GTP, 2'-deoxy-IMP and Hadacidin
Release Data : 2007-04-24
Compound :
mol_id molecule chains synonym
1 Adenylosuccinate Synthetase A IMP--aspartate ligase; AdSS; AMPSase
ec: 6.3.4.4
other_details: Fully ligated with GTP, 2'-deoxy-IMP, Hadacidin
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: purA, adeK
expression_system_vector_type: plasmid
Authors : Honzatko, R.B., Zhou, Y.
Keywords : Adenylosuccinate synthetase; ADSS; GTP; Hadacidin; 2'-deoxy-IMP, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases

Iancu, C.V.,Zhou, Y.,Borza, T.  et al.
(2006)  Biochemistry  45 : 11703 - 11711

PubMed: 16981730
DOI: 10.1021/bi0607498

Reaction

Chain : A
UniProt : P0A7D4 (PURA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2- dicarboxyethyl)-AMP + phosphate 6.3.4.4 HAMAP- Rule:MF_00011
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