Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
F83 (3r)-N-(4-chlorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
SAH S-adenosyl-L-homocysteine
Code : 2G8N
Header : TRANSFERASE
Title : Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy
Release Data : 2006-09-12
Compound :
mol_id molecule chains synonym
1 Phenylethanolamine N-methyltransferase A,B PNMTase, Noradrenaline N-methyltransferase
ec: 2.1.1.28
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_strain: BL21(DE3)pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: PNMT-His
Authors : Drinkwater, N., Gee, C.L., Martin, J.L.
Keywords : methyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.150 Å )
Citation :

Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase

Grunewald, G.L.,Seim, M.R.,Regier, R.C.  et al.
(2006)  J.Med.Chem.  49 : 5424 - 5433

PubMed: 16942016
DOI: 10.1021/jm060466d

Chain : A, B
UniProt : P11086 (PNMT_HUMAN)
Reaction : S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.