Brand  (β version)

PDB ID: 2G7N

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Ligands
Code Name Style Show Link
AG Silver ion PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 2G7N   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of the Light Chain of Botulinum Neurotoxin Serotype A Bound to small Molecule Inhibitors
Release Data : 2007-03-13
Compound :
mol_id molecule chains
1 Botulinum neurotoxin type A A
ec: 3.4.24.69
fragment: Light Chain A, residues 2-425
Source :
mol_id organism_scientific expression_system
1 Clostridium botulinum  (taxid:1491) Escherichia coli  (taxid:562)
gene: botA, atx, bna
expression_system_strain: BL21RIL (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET15b
Authors : Fu, Z., Baldwin, M.R., Boldt, G.E., Janda, K.D., Barbieri, J.T., Kim, J.-J.P.
Keywords : botulinum neurotoxin, zinc protease, SNAP25, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structure of the Light Chain of Botulinum Neurotoxin Serotype A bound to Small Molecule Inhibitors

Fu, Z.,Baldwin, M.R.,Boldt, G.E.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q45894 (BXA2_CLOBJ)
Reaction: EC: Evidence:
Physiological Direction:
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates. 3.4.24.69 PubMed:16846233
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