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Ligands
Code Name Style Show Link
H64 8-(6-bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine
Non-standard Residues
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Glycosylation
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Code : 2FWY   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64
Release Data : 2006-10-03
Compound :
mol_id molecule chains synonym
1 Heat shock protein HSP 90-alpha A HSP90 protein
fragment: N-terminal Domain Residues 1-236
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: HSPCA
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: PET-15b
Authors : Immormino, R.M., Gewirth, D.T.
Keywords : HSP90, GRP94, chaperone, purine, PU3, H64, H71
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.

Immormino, R.M.,Kang, Y.,Chiosis, G.  et al.
(2006)  J.Med.Chem.  49 : 4953 - 4960

PubMed: 16884307
DOI: 10.1021/jm060297x