Brand  (β version)

PDB ID: 2FR6

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
SO4 Sulfate ion PoSSuM
CTN 4-amino-1-beta-D-ribofuranosyl-2(1h)-pyrimidinone PoSSuM
URI Uridine PoSSuM
NH3 Ammonia PoSSuM
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Structure summary

Code : 2FR6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Mouse Cytidine Deaminase Complexed with Cytidine
Release Data : 2006-07-11
Compound :
mol_id molecule chains synonym
1 Cytidine deaminase A,B,C,D Cytidine aminohydrolase
ec: 3.5.4.5
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli BL21  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: pET-21c
Authors : Teh, A.H.
Keywords : CYTIDINE DEAMINASE, ZINC, CYTIDINE, URIDINE, PROTEIN-SUBSTRATE COMPLEX, SUBSTRATE-PRODUCT INTERMEDIATE, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.070 Å )
Citation :

The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse

Teh, A.H.,Kimura, M.,Yamamoto, M.  et al.
(2006)  Biochemistry  45 : 7825 - 7833

PubMed: 16784234
DOI: 10.1021/bi060345f

Reaction

Chain : A, B, C, D
UniProt : P56389 (CDD_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
cytidine + H(+) + H2O = NH4(+) + uridine 3.5.4.5 -
-
2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+) 3.5.4.5 -
-