Brand  (β version)

PDB ID: 2FQO

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
HYI (2s)-2-amino-4-[(2r,3r)-2,3-dihydroxy-3-N-hydroxycarbamoyl-propylmercapto]butyric acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2FQO   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of B. subtilis LuxS in complex with (2S)-2-Amino-4-[(2R,3R)-2,3-dihydroxy-3-N- hydroxycarbamoyl-propylmercapto]butyric acid
Release Data : 2006-05-30
Compound :
mol_id molecule chains synonym
1 S-ribosylhomocysteine lyase A Autoinducer-2 production protein luxS, AI-2 synthesis protein
ec: 4.4.1.21
Source :
mol_id organism_scientific expression_system
1 Bacillus subtilis  (taxid:1423) Escherichia coli BL21(DE3)  (taxid:469008)
gene: luxS
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET22B
Authors : Shen, G., Rajan, R., Zhu, J., Bell, C.E., Pei, D.
Keywords : LuxS, Quorum sensing, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.87 Å )
Citation :

Design and Synthesis of Substrate and Intermediate Analogue Inhibitors of S-Ribosylhomocysteinase

Shen, G.,Rajan, R.,Zhu, J.  et al.
(2006)  J.Med.Chem.  49 : 3003 - 3011

PubMed: 16686542
DOI: 10.1021/jm060047g

Reaction

Chain : A
UniProt : O34667 (LUXS_BACSU)
Reaction: EC: Evidence:
Physiological Direction:
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5- dihydroxypentane-2,3-dione + L-homocysteine 4.4.1.21 -
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