Brand  (β version)

PDB ID: 2FOI

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Ligands
Code Name Style Show Link
NAD Nicotinamide-adenine-dinucleotide PoSSuM
JPA 4-(2,4-dichlorophenoxy)-2'-methylbiphenyl-3-ol PoSSuM
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Structure summary

Code : 2FOI   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase.
Release Data : 2007-01-16
Compound :
mol_id molecule chains
1 enoyl-acyl carrier reductase A,B
ec: 1.3.1.9
fragment: N-terminal fragment, residues 97-216
mol_id molecule chains
2 enoyl-acyl carrier reductase C,D
ec: 1.3.1.9
fragment: C-terminal fragment, residues 97-156
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:36329) Escherichia coli  (taxid:562)
strain: 3D7
gene: PfENR
expression_system_strain: BL21(DE3) Codon+-RIL cells
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
mol_id organism_scientific expression_system
2 Plasmodium falciparum  (taxid:36329) Escherichia coli  (taxid:562)
strain: 3D7
gene: PfENR
expression_system_strain: BL21(DE3) Codon+-RIL cells
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
Authors : Freundlich, J.S., Shieh, H., Anderson, J.W., Kuo, M., Yu, M., Valderramos, J., Karagyozov, L., Tsai, H., Lucumi, E., Jacobs Jr., W.R., Schiehser, G.A., Jacobus, D.P., Fidock, D.A., Sacchettini, J.C.
Keywords : enoyl reductase, rossmann fold, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy.

Freundlich, J.S.,Wang, F.,Tsai, H.C.  et al.
(2007)  J.Biol.Chem.  282 : 25436 - 25444

PubMed: 17567585
DOI: 10.1074/jbc.M701813200