Brand  (β version)

PDB ID: 2FJN

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
073 (4-{(2s,4e)-2-(1h-1,2,3-benzotriazol-1-yl)-2-[4-(methoxycarbonyl)phenyl]-5-phenylpent-4-enyl}phenyl)(difluoro)methylphosphonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2FJN   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : The structure of phosphotyrosine phosphatase 1B in complex with compound 2
Release Data : 2006-01-17
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein phosphatase, non-receptor type 1 A,B Protein-tyrosine phosphatase 1B, PTP-1B
ec: 3.1.3.48
fragment: CATALYTIC DOMAIN (residues 1-298)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PTPN1, PTP1B
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
Authors : Asante-Appiah, E., Patel, S., Desponts, C., Taylor, J.M., Lau, C., Dufresne, C., Therien, M., Friesen, R., Becker, J.W., Leblanc, Y., Kennedy, B.P., Scapin, G.
Keywords : PHOSPHATASE, SECONDARY BINDING SITE, SELECTIVITY, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.

Asante-Appiah, E.,Patel, S.,Desponts, C.  et al.
(2006)  J.Biol.Chem.  281 : 8010 - 8015

PubMed: 16407290
DOI: 10.1074/jbc.M511827200

Reaction

Chain : A, B
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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