PDB ID: 2FJM
Hetero Atom Contents
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CL | Chloride ion | PoSSuM | |||
073 | (4-{(2s,4e)-2-(1h-1,2,3-benzotriazol-1-yl)-2-[4-(methoxycarbonyl)phenyl]-5-phenylpent-4-enyl}phenyl)(difluoro)methylphosphonic acid | PoSSuM |
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Download interaction data: 2FJM
Structure summary
Code : | 2FJM PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | The structure of phosphotyrosine phosphatase 1B in complex with compound 2 | ||||||||||||
Release Data : | 2006-01-17 | ||||||||||||
Compound : |
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Authors : | Asante-Appiah, E., Patel, S., Desponts, C., Taylor, J.M., Lau, C., Dufresne, C., Therien, M., Friesen, R., Becker, J.W., Leblanc, Y., Scapin, G. | ||||||||||||
Keywords : | PHOSPHATASE, SECONDARY BINDING SITE, SELECTIVITY, HYDROLASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.10 Å ) | ||||||||||||
Citation : |
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
Asante-Appiah, E.,Patel, S.,Desponts, C.
et al.
PubMed: 16407290 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P18031 (PTN1_HUMAN) | ||||||||
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