Het-PDB Navi2 (PDB: 2FJ1)

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Color scheme of protein:

Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
CTC	7-chlorotetracycline	PoSSuM
NI	Nickel (II) ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2FJ1

Code :

2FJ1 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION REGULATOR

Title :

Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II)

Release Data :

2007-01-09

Compound :

mol_id	molecule	chains
1	Tetracycline repressor protein class D	A
	fragment: residues 2-208 mutation: A2S

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: tetR expression_system_strain: K12 DELTA H1 DELTA TRP expression_system_vector_type: PLASMID expression_system_plasmid: PWH610

Authors :

Orth, P., Saenger, W., Palm, G.J., Hinrichs, W.

Keywords :

TRANSCRIPTION REGULATION, helix-turn-helix, metal coordination, TRANSCRIPTION REGULATOR

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex.

Palm, G.J.,Lederer, T.,Orth, P. et al.
(2008) J.Biol.Inorg.Chem. 13 : 1097 - 1110

Structure of the TET repressor-tetracycline complex and regulation of antibiotic resistance

Hinrichs, W.,Kisker, C.,Duevel, M. et al.
(1994) Science 264 : 418 - 420

PDB ID: 2FJ1