Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FRU Fructose
SO4 Sulfate ion
Modified Residues
Code Name Link
MSE Selenomethionine
Code : 2FIT
Header : CHROMOSOMAL TRANSLOCATION
Title : FHIT (FRAGILE HISTIDINE TRIAD PROTEIN)
Release Data : 1997-11-19
Compound :
mol_id molecule chains synonym
1 FRAGILE HISTIDINE PROTEIN A FHIT, FRAGILE HISTIDINE TRIAD PROTEIN
other_details: SELENOMETHIONYL FHIT WITH BOUND SULFATE IN ACTIVE SITE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FHIT
expression_system_strain: DL41
expression_system_plasmid: PGEX-2T
expression_system_gene: FHIT
other_details: EXPRESSED AS FUSION PROTEIN WITH GLUTATHIONE-S-TRANSFERASE
Authors : Lima, C.D., D'Amico, K.L., Naday, I., Rosenbaum, G., Westbrook, E.M., Hendrickson, W.A.
Keywords : FHIT, FRAGILE HISTIDINE TRIAD PROTEIN, PUTATIVE HUMAN TUMOR SUPPRESSOR, ADVANCED PHOTON SOURCE, APS, HIT PROTEIN FAMILY, PKCI, CHROMOSOMAL TRANSLOCATION
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.

Lima, C.D.,D'Amico, K.L.,Naday, I.  et al.
(1997)  Structure  5 : 763 - 774

PubMed: 9261067
DOI: 10.1016/S0969-2126(97)00231-1

Chain : A
UniProt : P49789 (FHIT_HUMAN)
Reaction : P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP.