Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CA Calcium ion
CL Chloride ion
MG Magnesium ion
NA Sodium ion
ZN Zinc ion
0G7 D-phenylalanyl-N-[(3s)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide
FUC Alpha-L-fucose
GLC Alpha-D-glucose
Modified Residues
Code Name Link
CGU Gamma-carboxy-glutamic acid
Code : 2FIR
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of DFPR-VIIa/sTF
Release Data : 2006-07-11
Compound :
mol_id molecule chains
1 Coagulation factor VII Light chain L
ec: 3.4.21.21
mol_id molecule chains
2 Coagulation factor VII Heavy Chain (EC 3.4.21.21) H
mol_id molecule chains synonym
3 Tissue factor T TF, Coagulation factor III, Thromboplastin, CD142 antigen
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F7
expression_system_common: Chinese hamster
expression_system_cell_line: BHK/VP16
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F7
expression_system_common: Chinese hamster
expression_system_cell_line: BHK/VP16
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: F3
Authors : Bajaj, S.P., Schmidt, A.E., Padmanabhan, K., Bajaj, M.S., Prevost, D., Schreuder, H.
Keywords : Factor VIIa, soluble tissue factor, oxyanion hole, serine protease, blood coagulation, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

High Resolution Structures of p-Aminobenzamidine- and Benzamidine-VIIa/Soluble Tissue Factor: Unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+ and Zn2+ sites in factor VIIa

Bajaj, S.P.,Schmidt, A.E.,Agah, S.  et al.
(2006)  J.Biol.Chem.  281 : 24873 - 24888

PubMed: 16757484
DOI: 10.1074/jbc.M509971200

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction : Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Chain : T
UniProt : P13726 (TF_HUMAN)
Reaction : -