Brand  (β version)

PDB ID: 2FBW

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
Y3P (~{z})-2-oxidanylbut-2-enedioic acid PoSSuM
K Potassium ion PoSSuM
AZI Azide ion PoSSuM
UNL Unknown ligand PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
NA Sodium ion PoSSuM
GOL Glycerol PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
CBE 2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Structure summary

Code : 2FBW   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Avian respiratory complex II with carboxin bound
Release Data : 2005-12-20
Compound :
mol_id molecule chains
1 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial A,N
ec: 1.3.5.1
mol_id molecule chains synonym
2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial B,O Iron-sulfur subunit of complex II,Ip
ec: 1.3.5.1
mol_id molecule chains
3 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C,P
mol_id molecule chains synonym
4 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial D,Q CybS,Succinate dehydrogenase complex subunit D,Succinate-ubiquinone oxidoreductase cytochrome b small subunit,Succinate-ubiquinone reductase membrane anchor subunit
Source :
mol_id organism_scientific organism_common
1 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
2 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
3 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
4 Gallus gallus  (taxid:9031) Chicken
Authors : Huang, L.S., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A.
Keywords : COMPLEX II, MEMBRANE PROTEIN, HEME PROTEIN, IRON SULFUR PROTEIN, CYTOCHROME B, OXIDOREDUCTASE, REDOX ENZYME, RESPIRATORY CHAIN, OXALOACETATE NITROPROPIONATE UBIQUINONE
Exp. method : X-RAY DIFFRACTION ( 2.06 Å )
Citation :

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.

Huang, L.S.,Sun, G.,Cobessi, D.  et al.
(2006)  J.Biol.Chem.  281 : 5965 - 5972

PubMed: 16371358
DOI: 10.1074/jbc.M511270200

Crystallization of mitochondrial respiratory complex II from chicken heart: a membrane-protein complex diffracting to 2.0 A

Huang, L.S.,Borders, T.M.,Shen, J.T.  et al.
(2005)  Acta Crystallogr.,Sect.D  61 : 380 - 387

Crystal structure of mitochondrial respiratory membrane protein complex II.

Sun, F.,Huo, X.,Zhai, Y.  et al.
(2005)  Cell(Cambridge,Mass.)  121 : 1043 - 1057

Reaction

Chain : A, N
UniProt : F1NPJ4
Reaction : -
Chain : B, O
UniProt : Q9YHT2 (SDHB_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 UniProtKB:P21912
-
Chain : C, P
UniProt : A0A3Q2U2Y6
Reaction : -
Chain : D, Q
UniProt : Q5ZIS0 (DHSD_CHICK)
Reaction : -