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Ligands
Code Name Style Show Link
5AD 5'-deoxyadenosine
GTP Guanosine-5'-triphosphate
MET Methionine
POP Pyrophosphate 2-
SF4 Iron/sulfur cluster
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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Code : 2FB3   PDBj   RCSB PDB   PDBe
Header : Ligand Binding Protein
Title : Structure of MoaA in complex with 5'-GTP
Release Data : 2006-05-09
Compound :
mol_id molecule chains synonym
1 Molybdenum cofactor biosynthesis protein A A,B MoaA
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:562)
gene: MoaA
expression_system_vector_type: plasmid
Authors : Haenzelmann, P., Schindelin, H.
Keywords : S-adenosylmethionine, TIM barrel, [4Fe-4S] clusters, 5'-GTP, 5'-deoxyadenosine, Ligand Binding Protein
Exp. method : X-RAY DIFFRACTION ( 2.349 Å )
Citation :

Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism

Haenzelmann, P.,Schindelin, H.
(2006)  Proc.Natl.Acad.Sci.USA  103 : 6829 - 6834

PubMed: 16632608
DOI: 10.1073/pnas.0510711103

Chain : A, B
UniProt : P69848 (MOAA_STAA8)
Reaction: EC: Evidence:
Physiological Direction:
AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L- methionine 4.1.99.22 PubMed:23627491, PubMed:25697423
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