Brand  (β version)

PDB ID: 2F4O

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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PHQ Benzyl chlorocarbonate
CF0 Fluoromethane

Structure summary

Code : 2F4O   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs
Release Data : 2006-03-07
Compound :
mol_id molecule chains
1 peptide N-glycanase A
ec: 3.5.1.52
fragment: Catalytic domain, residues 164-450
mol_id molecule chains synonym
2 XP-C repair complementing complex 58 kDa protein B mHR23B, UV excision repair protein RAD23 homolog B p58
fragment: XPCB domain, residues 273-332
mol_id molecule chains
3 PHQ-VAL-ALA-ASP-CF0 I
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
expression_system_strain: BL21-CodonPlus-RIL
expression_system_vector_type: PLASMID
expression_system_plasmid: pET21b
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
gene: Rad23b, Mhr23b
expression_system_strain: BL21-CodonPlus-RIL
expression_system_vector_type: PLASMID
expression_system_plasmid: pTYb1
mol_id organism_scientific
3
synthetic: yes
Authors : Zhao, G., Zhou, X., Wang, L., Kisker, C., Lennarz, W.J., Schindelin, H.
Keywords : GLYCOPROTEINS, UBIQUITIN-DEPENDENT PROTEIN DEGRADATION, NUCLEOTIDE EXCISION REPAIR, PEPTIDE:N-GLYCANASE, TRANSGLUTAMINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.26 Å )
Citation :

Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways.

Zhao, G.,Zhou, X.,Wang, L.  et al.
(2006)  J.Biol.Chem.  281 : 13751 - 13761

PubMed: 16500903
DOI: 10.1074/jbc.M600137200

Reaction

Chain : B
UniProt : P54728 (RD23B_MOUSE)
Reaction : -