Brand  (β version)

PDB ID: 2EGH

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Ligands
Code Name Style Show Link
FOM 3-[formyl(hydroxy)amino]propylphosphonic acid PoSSuM
MG Magnesium ion PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 2EGH   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with a magnesium ion, NADPH and fosmidomycin
Release Data : 2007-06-19
Compound :
mol_id molecule chains synonym
1 1-deoxy-D-xylulose 5-phosphate reductoisomerase A,B DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C- methyl-D-erythritol 4-phosphate synthase
ec: 1.1.1.267
Source :
mol_id organism_scientific expression_system
1 Escherichia coli str. K12 substr.  (taxid:316407) Escherichia coli  (taxid:562)
strain: W3110
gene: dxr
expression_system_strain: M15
expression_system_vector_type: plasmid
expression_system_plasmid: pQE30
Authors : Yajima, S., Hara, K., Iino, D., Sasaki, Y., Kuzuyama, T., Seto, H.
Keywords : Protein-inhibitor complex, Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin

Yajima, S.,Hara, K.,Iino, D.  et al.
(2007)  Acta Crystallogr.,Sect.F  63 : 466 - 470

PubMed: 17554164
DOI: 10.1107/S1744309107024475

Reaction

Chain : A, B
UniProt : P45568 (DXR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH 1.1.1.267 PubMed:10631325, PubMed:10787409, PubMed:9707569
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