Brand  (β version)

PDB ID: 2EAU

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Ligands
Code Name Style Show Link
CZA (6ar,11as,11br)-10-acetyl-9-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-11h-pyrrolo[1',2':2,3]isoindolo[4,5,6-Cd]indol-11-one PoSSuM
PTY Phosphatidylethanolamine PoSSuM
Non-standard Residues
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Glycosylation
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ACE Acetyl group

Structure summary

Code : 2EAU   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of the SR CA2+-ATPASE with bound CPA in the presence of curcumin
Release Data : 2007-03-27
Compound :
mol_id molecule chains synonym
1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 A Calcium pump 1, SERCA1, SR Ca(2+)-ATPase 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+)ATPase
ec: 3.6.3.8
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: SKELETAL MUSCLE (WHITE)
Authors : Takahashi, M., Kondou, Y., Toyoshima, C.
Keywords : MEMBRANE PROTEIN, P-TYPE ATPASE, HAD FOLD, Ca2+, ion pump, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors

Takahashi, M.,Kondou, Y.,Toyoshima, C.
(2007)  Proc.Natl.Acad.Sci.Usa  104 : 5800 - 5805

PubMed: 17389383
DOI: 10.1073/pnas.0700979104

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

Toyoshima, C.,Nakasako, M.,Nomura, H.  et al.
(2000)  Nature  405 : 647 - 655

PubMed: 10864315
DOI: 10.1038/35015017

Structural changes in the calcium pump accompanying the dissociation of calcium

Toyoshima, C.,Nomura, H.
(2002)  Nature  418 : 605 - 611

PubMed: 12167852
DOI: 10.1038/nature00944

Crystal structure of the calcium pump with a bound ATP analogue

Toyoshima, C.,Mizutani, T.
(2004)  Nature  430 : 529 - 535

PubMed: 15229613
DOI: 10.1038/nature02680

Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues

Toyoshima, C.,Nomura, H.,Tsuda, T.
(2004)  Nature  432 : 361 - 368

PubMed: 15448704
DOI: 10.1038/nature02981

Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+)

Obara, K.,Miyashita, N.,Xu, C.  et al.
(2005)  Proc.Natl.Acad.Sci.Usa  102 : 14489 - 14496

PubMed: 16150713
DOI: 10.1073/pnas.0506222102

Reaction

Chain : A
UniProt : P04191 (AT2A1_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate 7.2.2.10 PubMed:10914677, PubMed:11438520, PubMed:15189864, PubMed:18075584, PubMed:23996003, PubMed:29081402, PubMed:8117720
left-to-right PubMed:10914677