Het-PDB Navi2 (PDB: 2EA4)

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Ligands
Code	Name		Style	Show	Link
F79	2-(2-aminoethoxy)-3-ethyl-6-{[(4-fluorophenyl)sulfonyl]amino}benzoic acid				PoSSuM
MN	Manganese (II) ion				PoSSuM

Non-standard Residues
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Download interaction data: 2EA4

Code :

2EA4 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

H-MetAP2 complexed with A797859

Release Data :

2008-02-05

Compound :

mol_id	molecule	chains	synonym
1	Methionine aminopeptidase 2	A	MetAP 2, Peptidase M 2, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2
	ec: 3.4.11.18 fragment: residues 110-478

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_vector_type: plasmid

Authors :

Park, C.H.

Keywords :

Protein-ligand complex, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids

Wang, G.T.,Mantei, R.A.,Kawai, M. et al.
(2007) Bioorg.Med.Chem.Lett. 17 : 2817 - 2822

Chain :

UniProt :

P50579 (MAP2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.	3.4.11.18	HAMAP-Rule:MF_03175, PubMed:20521764
	-	HAMAP-Rule:MF_03175, PubMed:20521764

PDB ID: 2EA4