Brand  (β version)

PDB ID: 2E8T

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Ligands
Code Name Style Show Link
FPS S-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl] trihydrogen thiodiphosphate PoSSuM
IPE 3-methylbut-3-enyl trihydrogen diphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2E8T   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium, FsPP and IPP
Release Data : 2007-06-12
Compound :
mol_id molecule chains synonym
1 Geranylgeranyl pyrophosphate synthetase A,B GGPP synthetase, GGPPSase, Geranylgeranyl diphosphate synthase, BET2 suppressor protein 1
ec: 2.5.1.30
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21 (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET32/LIC
Authors : Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Keywords : prenyltransferase, farnesyl pyrophosphate, bisphosphonate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.13 Å )
Citation :

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Guo, R.T.,Cao, R.,Liang, P.H.  et al.
(2007)  Proc.Natl.Acad.Sci.Usa  104 : 10022 - 10027

PubMed: 17535895
DOI: 10.1073/pnas.0702254104

Reaction

Chain : A, B
UniProt : Q12051 (GGPPS_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 -
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(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 -
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(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate 2.5.1.29 PubMed:7665600
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