Het-PDB Navi2 (PDB: 2E7F)

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Ligands
Code	Name		Style	Show	Link
C2F	5-methyl-5,6,7,8-tetrahydrofolic acid				PoSSuM
CA	Calcium ion				PoSSuM

Non-standard Residues
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Download interaction data: 2E7F

Code :

2E7F PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution

Release Data :

2007-01-30

Compound :

mol_id	molecule	chains
1	5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase	A,B

Source :

mol_id	organism_scientific	expression_system
1	Moorella thermoacetica (taxid:1525)	Escherichia coli (taxid:562)
	gene: MeTr, acsE expression_system_strain: B834(DE3)pLysS(met-) expression_system_vector_type: plasmid expression_system_plasmid: pET3a

Authors :

Doukov, T.I., Drennan, C.L., Hemmi, H., Ragsdale, S.W.

Keywords :

Methyltetrahydrofolate-protein complex, corrionoid, vitamin B12, TIM Barrel, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.

Doukov, T.I.,Hemmi, H.,Drennan, C.L. et al.
(2007) J.Biol.Chem. 282 : 6609 - 6618

PubMed: 17172470
DOI: 10.1074/jbc.M609828200

Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase

Doukov, T.I.,Seravalli, J.,Stezowski, J.J. et al.
(2000) Structure 8 : 817 - 830

PubMed: 10997901
DOI: 10.1016/S0969-2126(00)00172-6

PDB ID: 2E7F

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