Brand  (β version)

PDB ID: 2E25

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Ligands
Code Name Style Show Link
FOT 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
KCX Lysine nz-carboxylic acid
Glycosylation
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Structure summary

Code : 2E25   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : The Crystal Structure of the T109S mutant of E. coli Dihydroorotase complexed with an inhibitor 5-fluoroorotate
Release Data : 2007-03-13
Compound :
mol_id molecule chains synonym
1 Dihydroorotase A DHOase
ec: 3.5.2.3
mutation: T109S
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: PYRC
expression_system_strain: X7014a
expression_system_vector_type: Plasmid
expression_system_plasmid: pBluescript
Authors : Lee, M., Maher, M.J., Guss, J.M.
Keywords : TIM barrel, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form

Lee, M.,Maher, M.J.,Guss, J.M.
(2007)  Acta Crystallogr.,Sect.F  63 : 154 - 161

PubMed: 17329804
DOI: 10.1107/S1744309107004009

Reaction

Chain : A
UniProt : P05020 (PYRC_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate 3.5.2.3 HAMAP-Rule:MF_00219, PubMed:15610022, PubMed:6142052
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