Brand  (β version)

PDB ID: 2DQZ

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
COA Coenzyme a PoSSuM
F Fluoride ion PoSSuM
HTQ Homotropine PoSSuM
PLM Palmitic acid PoSSuM
SO4 Sulfate ion PoSSuM
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM
SIA N-acetyl-alpha-neuraminic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2DQZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate
Release Data : 2006-08-29
Compound :
mol_id molecule chains synonym
1 Liver carboxylesterase 1 A,B,C Acyl coenzyme A:cholesterol acyltransferase, ACAT, Monocyte/macrophage serine esterase, HMSE, Serine esterase 1, Brain carboxylesterase hBr1, Triacylglycerol hydrolase, TGH, Egasyn
ec: 3.1.1.1
fragment: residues 19-561
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
expression_system_common: Fall armyworm
expression_system_cell_line: sf9
expression_system_vector_type: BACULOVIRUS
Authors : Bencharit, S., Redinbo, M.R.
Keywords : cholesterol, esterase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1

Bencharit, S.,Edwards, C.C.,Morton, C.L.  et al.
(2006)  J.Mol.Biol.  363 : 201 - 214

PubMed: 16962139
DOI: 10.1016/j.jmb.2006.08.025

Reaction

Chain : A, B, C
UniProt : P23141 (EST1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a carboxylic ester + H2O = a carboxylate + an alcohol + H(+) 3.1.1.1 PROSITE-ProRule:PRU10039, PubMed:7980644, PubMed:9169443, PubMed:9490062
-
4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+) 3.1.1.56 PubMed:18762277, PubMed:9169443
-
a cholesterol ester + H2O = a fatty acid + cholesterol + H(+) 3.1.1.13 PubMed:11015575, PubMed:16024911, PubMed:16971496, PubMed:18762277
left-to-right PubMed:18762277
cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+) - PubMed:11015575, PubMed:16024911, PubMed:16971496, PubMed:18762277
left-to-right PubMed:11015575
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) - PubMed:21049984
left-to-right
H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2 - PubMed:21049984
left-to-right
H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha - PubMed:21049984
left-to-right