Brand  (β version)

PDB ID: 2DDH

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
HXD (3r)-3-hydroxydodecanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 2DDH   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Acyl-CoA oxidase complexed with 3-OH-dodecanoate
Release Data : 2006-03-28
Compound :
mol_id molecule chains
1 Acyl-CoA oxidase A
ec: 1.3.3.6
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: pET11d
Authors : Keiji, T., Nakajima, Y., Miyahara, I., Hirotsu, K.
Keywords : BETA BARREL, ALPHA up-down BUNDLE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.070 Å )
Citation :

Three-Dimensional Structure of Rat-Liver Acyl-CoA Oxidase in Complex with a Fatty Acid: Insights into Substrate-Recognition and Reactivity toward Molecular Oxygen.

Tokuoka, K.,Nakajima, Y.,Hirotsu, K.  et al.
(2006)  J.Biochem.(Tokyo)  139 : 789 - 795

PubMed: 16672280
DOI: 10.1093/jb/mvj088

Reaction

Chain : A
UniProt : P07872 (ACOX1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2 1.3.3.6 PubMed:16672280, PubMed:7503725, PubMed:1400324, PubMed:7462191
left-to-right PubMed:11872165, PubMed:1400324, PubMed:16672280, PubMed:7462191, PubMed:7503725
hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2 - PubMed:1400324
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[Isoform 1]
hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2 		- PubMed:7503725
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[Isoform 2]
hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2 		- PubMed:7503725
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[Isoform 1]
dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2 		- PubMed:7503725
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[Isoform 2]
dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2 		- PubMed:16672280, PubMed:7503725
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[Isoform 1]
O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2 		- PubMed:7503725
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[Isoform 1]
decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2 		- PubMed:7503725
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[Isoform 1]
O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2 		- PubMed:7503725
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[Isoform 2]
O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2 		- PubMed:7503725
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hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2 - PubMed:1400324
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O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2 - PubMed:1400324
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glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2 - PubMed:1400324
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hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2 - PubMed:1400324
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O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2 - PubMed:7462191
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[Isoform 2]
O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2 		- PubMed:7503725
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(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2 - UniProtKB:Q15067
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(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 - UniProtKB:Q9R0H0
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