Brand  (β version)

PDB ID: 2D3Z

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Ligands
Code Name Style Show Link
FIH 5-(4-fluorophenyl)-3-{[(4-methylphenyl)sulfonyl]amino}thiophene-2-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2D3Z   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside analogue inhibitor
Release Data : 2006-08-01
Compound :
mol_id molecule chains synonym
1 polyprotein A,B NS5B
ec: 2.7.7.48
fragment: RNA-dependent RNA polymerase(Residues 2420-2989)
Source :
mol_id organism_scientific expression_system
1 Hepatitis C virus  (taxid:11103) Escherichia coli BL21(DE3)  (taxid:469008)
gene: TYPE 1B
expression_system_strain: BL21 (DE3)
Authors : Biswal, B.K., Wang, M., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G.
Keywords : HEPATITIS C VIRUS, RNA POLYMERASE, ENZYME INHIBITION, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

Biswal, B.K.,Wang, M.,Cherney, M.M.  et al.
(2006)  J.Mol.Biol.  361 : 33 - 45

PubMed: 16828488
DOI: 10.1016/j.jmb.2006.05.074

Reaction

Chain : A, B
UniProt : Q99AU2 (Q99AU2_9HEPC)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + phosphate + H(+) 3.6.4.13 ARBA:ARBA00047984
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Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 3.4.21.98 ARBA:ARBA00001117
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + phosphate + H(+) 3.6.1.15 ARBA:ARBA00047631
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000256 | ARBA:ARBA00001946
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Zn(2+) ECO:0000256 | ARBA:ARBA00001947
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