Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CCT 5-(4-cyanophenyl)-3-{[(2-methylphenyl)sulfonyl]amino}thiophene-2-carboxylic acid
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 2D3U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor
Release Data : 2006-08-01
Compound :
mol_id molecule chains synonym
1 polyprotein A,B NS5B
ec: 2.7.7.48
fragment: RNA-dependent RNA polymerase(Residues 2420-2989)
Source :
mol_id organism_scientific expression_system
1 Hepatitis C virus  (taxid:11103) Escherichia coli BL21  (taxid:511693)
gene: Type 1B
expression_system_strain: BL21
Authors : Biswal, B.K., Wang, M., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G.
Keywords : Hepatitis C Virus, RNA-dependent RNA polymerase, Enzyme inhibition, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

Biswal, B.K.,Wang, M.,Cherney, M.M.  et al.
(2006)  J.Mol.Biol.  361 : 33 - 45

PubMed: 16828488
DOI: 10.1016/j.jmb.2006.05.074

Chain : A, B
UniProt : Q99AU2 (Q99AU2_9HEPC)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 ARBA:ARBA00001556
-
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 3.4.21.98 ARBA:ARBA00001117
-
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 ARBA:ARBA00001491
-