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Ligands
Code Name Style Show Link
ZN Zinc ion
CA Calcium ion
FA4 Sm-25453
Non-standard Residues
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Glycosylation
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Code : 2D1O   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Stromelysin-1 (MMP-3) complexed to a hydroxamic acid inhibitor
Release Data : 2006-06-27
Compound :
mol_id molecule chains synonym
1 Stromelysin-1 A,B Matrix metalloproteinase-3, MMP-3, Transin-1, SL-1
ec: 3.4.24.17
fragment: C-Terminal catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Kohno, T., Hochigai, H., Yamashita, E., Tsukihara, T., Kanaoka, M.
Keywords : hydorolase metalloprotease, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.02 Å )
Citation :

Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453

Kohno, T.,Hochigai, H.,Yamashita, E.  et al.
(2006)  Biochem.Biophys.Res.Commun.  344 : 315 - 322

PubMed: 16603129
DOI: 10.1016/j.bbrc.2006.03.098

Chain : A, B
UniProt : P08254 (MMP3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage where P1', P2' and P3' are hydrophobic residues. 3.4.24.17 PubMed:1371271, PubMed:21330369
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