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Ligands
Code Name Style Show Link
GOL Glycerol
IZE N-{(1s)-2-{4-[(5r)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]ethyl}-2,2,2-trifluoroacetamide
MG Magnesium ion
Non-standard Residues
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Code : 2CNG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
Release Data : 2006-09-27
Compound :
mol_id molecule chains synonym
1 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 A PROTEIN TYROSINE PHOSPHATASE 1B, PTP-1B
ec: 3.1.3.48
fragment: CATALYTIC DOMAIN, RESIDUES 1-321
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Ala, P.J., Gonneville, L., Hillman, M., Becker-Pasha, M., Yue, E.W., Douty, B., Wayland, B., Polam, P., Crawley, M.L., McLaughlin, E., Sparks, R.B., Glass, B., Takvorian, A., Combs, A.P., Burn, T.C., Hollis, G.F., Wynn, R.
Keywords : POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.

Ala, P.J.,Gonneville, L.,Hillman, M.  et al.
(2006)  J.Biol.Chem.  281 : 38013

PubMed: 17028182
DOI: 10.1074/JBC.M607913200

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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