PDB ID: 2CMF
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Structure summary
Code : | 2CMF PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (5 carbon linker) | ||||||||||||
Release Data : | 2006-09-04 | ||||||||||||
Compound : |
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Source : |
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Authors : | Rydberg, E.H., Brumshtein, B., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L. | ||||||||||||
Keywords : | SERINE ESTERASE, SERINE HYDROLASE, ALZHEIMER'S DISEASE, NERVE, MUSCLE, SYNAPSE, MEMBRANE, HYDROLASE, GPI-ANCHOR, LIPOPROTEIN, GLYCOPROTEIN, CHOLINESTERASE, ALTERNATIVE SPLICING, NEUROTRANSMITTER DEGRADATION | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.50 Å ) | ||||||||||||
Citation : |
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Rydberg, E.H.,Brumshtein, B.,Greenblatt, H.M.
et al.
PubMed: 16942022 |
Reaction
Chain : | A | ||||||||
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UniProt : | P04058 (ACES_TETCF) | ||||||||
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