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Ligands
Code Name Style Show Link
F11 N,N'-di-1,2,3,4-tetrahydroacridin-9-ylpentane-1,5-diamine
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 2CMF   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (5 carbon linker)
Release Data : 2006-09-04
Compound :
mol_id molecule chains synonym
1 ACETYLCHOLINESTERASE A ACHE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common
1 TORPEDO CALIFORNICA  (taxid:7787) PACIFIC ELECTRIC RAY
variant: G2 FORM
organ: ELECTRIC ORGAN
tissue: ELECTROPLAQUE
Authors : Rydberg, E.H., Brumshtein, B., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L.
Keywords : SERINE ESTERASE, SERINE HYDROLASE, ALZHEIMER'S DISEASE, NERVE, MUSCLE, SYNAPSE, MEMBRANE, HYDROLASE, GPI-ANCHOR, LIPOPROTEIN, GLYCOPROTEIN, CHOLINESTERASE, ALTERNATIVE SPLICING, NEUROTRANSMITTER DEGRADATION
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Rydberg, E.H.,Brumshtein, B.,Greenblatt, H.M.  et al.
(2006)  J. Med. Chem.  49 : 5491 - 5500

PubMed: 16942022
DOI: 10.1021/jm060164b

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-