Brand  (β version)

PDB ID: 2CHX

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Ligands
Code Name Style Show Link
090 N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-C] quinazolin-5-yl)nicotinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2CHX   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90
Release Data : 2006-05-22
Compound :
mol_id molecule chains synonym
1 PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM A PHOSPHOINOSITIDE 3-KINASE, PI3-KINASE P110 SUBUNIT GAMMA, PTDINS-3-KINASE P110, PI3K, PI3KGAMMA
ec: 2.7.1.137, 2.7.1.153
fragment: HUMAN PI-3K GAMMA CATALYTIC SUBUNIT, RESIDUES 144-1102
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_strain: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PVL1393
Authors : Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.
Keywords : PHOSPHOINOSITIDE, KINASE, LIPID, INHIBITOR, 3-KINASE, SIGNALING, QUINAZOLINONE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling

Knight, Z.A.,Gonzalez, B.,Feldman, M.E.  et al.
(2006)  Cell(Cambridge,Mass.)  125 : 733

PubMed: 16647110
DOI: 10.1016/J.CELL.2006.03.035

Reaction

Chain : A
UniProt : P48736 (PK3CG_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 PubMed:11277933, PubMed:16123124
left-to-right PubMed:11277933
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 PubMed:15135396, PubMed:16123124, PubMed:31554793
left-to-right PubMed:15135396
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+) 2.7.1.154 PubMed:16123124
left-to-right
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12502714, PubMed:16094730
left-to-right PubMed:12502714