Het-PDB Navi2 (PDB: 2CAN)

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Ligands
Code	Name		Style	Show	Link
CAN	Canaline				PoSSuM
PLP	Pyridoxal-5'-phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2CAN

Code :

2CAN PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH L-CANALINE

Release Data :

1998-06-03

Compound :

mol_id	molecule	chains
1	ORNITHINE AMINOTRANSFERASE	A,B,C
	ec: 2.6.1.13 other_details: BOUND INHIBITOR L-CANALINE

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Shah, S.A., Shen, B.W., Brunger, A.T.

Keywords :

TRANSFERASE, ORNITHINE AMINOTRANSFERASE, UREA CYCLE, PYRIDOXAL-5'-PHOSPHATE

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.

Shah, S.A.,Shen, B.W.,Brunger, A.T.
(1997) Structure 5 : 1067 - 1075

Chain :

A, B, C

UniProt :

P04181 (OAT_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L- glutamate	2.6.1.13	PubMed:1737786, PubMed:23076989
	right-to-left	PubMed:1737786
Cofactor:	Evidence:	Note:
pyridoxal 5'-phosphate	ECO:0000269 \| PubMed:9514741	-

PDB ID: 2CAN