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Ligands
Code Name Style Show Link
CAN Canaline
PLP Pyridoxal-5'-phosphate
Non-standard Residues
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Glycosylation
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Code : 2CAN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH L-CANALINE
Release Data : 1998-06-03
Compound :
mol_id molecule chains
1 ORNITHINE AMINOTRANSFERASE A,B,C
ec: 2.6.1.13
other_details: BOUND INHIBITOR L-CANALINE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Shah, S.A., Shen, B.W., Brunger, A.T.
Keywords : TRANSFERASE, ORNITHINE AMINOTRANSFERASE, UREA CYCLE, PYRIDOXAL-5'-PHOSPHATE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.

Shah, S.A.,Shen, B.W.,Brunger, A.T.
(1997)  Structure  5 : 1067 - 1075

PubMed: 9309222
DOI: 10.1016/S0969-2126(97)00258-X

Chain : A, B, C
UniProt : P04181 (OAT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5- semialdehyde 2.6.1.13 PubMed:1737786, PubMed:23076989
right-to-left PubMed:1737786