Het-PDB Navi2 (PDB: 2C8Z)

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Ligands
Code	Name	Link
C2A	1-(3-chlorophenyl)methanamine	PoSSuM
DMS	Dimethyl sulfoxide	PoSSuM
NA	Sodium ion	PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
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Download interaction data: 2C8Z

Code :

2C8Z PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

thrombin inhibitors

Release Data :

2006-07-04

Compound :

mol_id	molecule	chains
1	THROMBIN, LIGHT CHAIN	A
	ec: 3.4.21.5 fragment: FRAGMENT ALPHA THROMBIN, RESIDUES 328-363

mol_id	molecule	chains
2	THROMBIN HEAVY CHAIN	B
	ec: 3.4.21.5 fragment: FRAGMENT ALPHA THROMBIN, RESIDUES 364-622

mol_id	molecule	chains	synonym
3	HIRUDIN VARIANT-2	I	HIRUGEN
	fragment: PEPTIDE FRAGMENT OF HIRUGEN, RESIDUES 61-72

Source :

mol_id	organism_scientific	organism_common
1	HOMO SAPIENS (taxid:9606)	HUMAN
	tissue: BLOOD PLASMA

mol_id	organism_scientific	organism_common
2	HOMO SAPIENS (taxid:9606)	HUMAN
	tissue: BLOOD PLASMA

mol_id	organism_scientific	organism_common
3	HIRUDO MEDICINALIS (taxid:6421)	MEDICINAL LEECH

Authors :

Howard, N., Abell, C., Blakemore, W., Carr, R., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., van Montfort, R.L.M.

Keywords :

PROTEASE, BLOOD COAGULATION, THROMBIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.14 Å )

Citation :

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors

Howard, N.,Abell, C.,Blakemore, W. et al.
(2006) J.Med.Chem. 49 : 1346

PubMed: 16480269
DOI: 10.1021/JM050850V

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

Chain :	I
UniProt :	P09945 (HIRV2_HIRME)
Reaction :	-

PDB ID: 2C8Z

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