Brand  (β version)

PDB ID: 2C6Z

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Ligands
Code Name Style Show Link
CIR Citrulline PoSSuM
CIT Citric acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2C6Z   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : crystal structure of dimethylarginine dimethylaminohydrolase I in complex with citrulline
Release Data : 2006-05-17
Compound :
mol_id molecule chains synonym
1 NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1 A DIMETHYLARGININE DIMETHYLAMINOHYDROLASE I, DIMETHYLARGININASE 1, DDAHI, DDAH-1
ec: 3.5.3.18
Source :
mol_id organism_scientific organism_common
1 BOS TAURUS  (taxid:9913) BOVINE
organ: BRAIN
Authors : Frey, D., Braun, O., Briand, C., Vasak, M., Grutter, M.G.
Keywords : DDAH I, NO, NOS, ADMA, MMA, ACETYLATION, HYDROLASE, METAL-BINDING, S-NITROSYLATION, ZINC
Exp. method : X-RAY DIFFRACTION ( 1.2 Å )
Citation :

Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inbitors

Frey, D.,Braun, O.,Briand, C.  et al.
(2006)  Structure  14 : 901

PubMed: 16698551
DOI: 10.1016/J.STR.2006.03.006

Reaction

Chain : A
UniProt : P56965 (DDAH1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline 3.5.3.18 PubMed:9537995
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H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine 3.5.3.18 PubMed:9537995
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