Brand  (β version)

PDB ID: 2C5V

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Ligands
Code Name Style Show Link
CK4 4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine PoSSuM
Non-standard Residues
Code Name Show
ABA Alpha-aminobutyric acid
PFF 4-fluoro-L-phenylalanine
Glycosylation
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Modification
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NH2 Amino group

Structure summary

Code : 2C5V   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
Release Data : 2006-03-01
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A,C CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
ec: 2.7.1.37
mol_id molecule chains synonym
2 CYCLIN A2 B,D CYCLIN A
mol_id molecule chains
3 ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2 F,H
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific
3 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
Authors : Kontopidis, G., McInnes, C., Pandalaneni, S.R., McNae, I., Gibson, D., Mezna, M., Thomas, M., Wood, G., Wang, S., Walkinshaw, M.D., Fischer, P.M.
Keywords : ATP-BINDING, CELL CYCLE, CELL DIVISION, COMPLEX (KINASE-CYCLIN), CYCIN A, CYCLIN, DRUG DESIGN, LIGAND EXCHANGE, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, COMPLEX (TRANSFERASE-CYCLIN)
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design.

Kontopidis, G.,Mcinnes, C.,Pandalaneni, S.R.  et al.
(2006)  Chem.Biol.  13 : 201

PubMed: 16492568
DOI: 10.1016/J.CHEMBIOL.2005.11.011

Reaction

Chain : A, C
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
Chain : B, D
UniProt : P20248 (CCNA2_HUMAN)
Reaction : -