Het-PDB Navi2 (PDB: 2C5O)

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Ligands
Code	Name		Style	Show	Link
CK2	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2C5O

Code :

2C5O PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design

Release Data :

2006-03-01

Compound :

mol_id	molecule	chains	synonym
1	CELL DIVISION PROTEIN KINASE 2	A,C	CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
	ec: 2.7.1.37 other_details: TRIAZOL-1-METHYL-PYRIMIDIN INHIBITOR

mol_id	molecule	chains	synonym
2	CYCLIN A2	B,D	CYCLIN A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_vector_type: BACULOVIRUS

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

Authors :

Kontopidis, G., McInnes, C., Pandalaneni, S.R., McNae, I., Gibson, D., Mezna, M., Thomas, M., Wood, G., Wang, S., Walkinshaw, M.D., Fischer, P.M.

Keywords :

DIFFERENTIAL INHIBITION, TRANSFERASE, CDK2, ATP-BINDING, CELL CYCLE, CELL DIVISION, POLYMORPHISM, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN, KINASE, MITOSIS, CYCLIN

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design.

Kontopidis, G.,Mcinnes, C.,Pandalaneni, S.R. et al.
(2006) Chem.Biol. 13 : 201

PubMed: 16492568
DOI: 10.1016/J.CHEMBIOL.2005.11.011

Chain :	B, D
UniProt :	P20248 (CCNA2_HUMAN)
Reaction :	-

PDB ID: 2C5O

Hetero Atom Contents

Structure summary

Reaction