Brand  (β version)

PDB ID: 2C5F

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Ligands
Code Name Style Show Link
CHH N,N,N-trimethyl-4-oxopentan-1-aminium PoSSuM
NWA 4,4-dihydroxy-N,N,N-trimethylpentan-1-aminium PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 2C5F   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Torpedo californica acetylcholinesterase in complex with a non hydrolysable substrate analogue, 4-oxo-N,N,N-trimethylpentanaminium
Release Data : 2006-06-14
Compound :
mol_id molecule chains synonym
1 ACETYLCHOLINESTERASE A ACHE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common
1 TORPEDO CALIFORNICA  (taxid:7787) PACIFIC ELECTRIC RAY
variant: G2 FORM
organ: ELECTRIC ORGAN
tissue: ELECTROPLAQUE
Authors : Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M.
Keywords : HYDROLASE, SERINE ESTERASE, SYNAPSE, MEMBRANE, NEUROTRANSMITTER CLEAVAGE, ALPHA/BETA HYDROLASE, SUBSTRATE HYDROLYSIS, MICHAELIS-MENTEN COMPLEX, SUBSTRATE INHIBITION, ALTERNATIVE SPLICING, GLYCOPROTEIN, GPI-ANCHOR, LIPOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.

Colletier, J.P.,Fournier, D.,Greenblatt, H.M.  et al.
(2006)  Embo J.  25 : 2746

PubMed: 16763558
DOI: 10.1038/SJ.EMBOJ.7601175

Reaction

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-