Brand  (β version)

PDB ID: 2C3C

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Ligands
Code Name Style Show Link
ACN Acetone PoSSuM
COM 1-thioethanesulfonic acid PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 2C3C   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : 2.01 Angstrom X-ray crystal structure of a mixed disulfide between coenzyme M and NADPH-dependent oxidoreductase 2-ketopropyl coenzyme M carboxylase
Release Data : 2005-12-12
Compound :
mol_id molecule chains synonym
1 2-OXOPROPYL-COM REDUCTASE A,B NADPH\:2-KETOPROPYL COENZYME M CARBOXYLASE/ OXIDOREDUCTASE, 2-KPCC, ALIPHATIC EPOXIDE CARBOXYLATION COMPONENT II
ec: 1.8.1.5
Source :
mol_id organism_scientific
1 XANTHOBACTER AUTOTROPHICUS  (taxid:78245)
strain: PY2
atcc: 35674
Authors : Pandey, A.S., Nocek, B., Clark, D.D., Ensign, S.A., Peters, J.W.
Keywords : OXIDOREDUCTASE, MIXED DISULFIDE, COENZYME M, REDOX-ACTIVE CENTER, FAD
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Mechanistic Implications of the Structure of the Mixed-Disulfide Intermediate of the Disulfide Oxidoreductase, 2-Ketopropyl-Coenzyme M Oxidoreductase/Carboxylase.

Pandey, A.S.,Nocek, B.,Clark, D.D.  et al.
(2006)  Biochemistry  45 : 113

PubMed: 16388586
DOI: 10.1021/BI051518O

Reaction

Chain : A, B
UniProt : Q56839 (XECC_XANP2)
Reaction: EC: Evidence:
Physiological Direction:
coenzyme M + acetoacetate + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH 1.8.1.5 PubMed:10411892
right-to-left
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:9150202
Binds 1 FAD per subunit.